List of Antiviral Nucleoside Analogues

HIV activity

Structure	Activity	Publications		Stage
	HIV (cell-free HIV-RT assay) IC₅₀ up to 0.41 µM	S.J. Keane, A. Ford, N.D. Mullins, N.M. Maguire, T. Legigan, J. Balzarini, A.R. Maguire Design and Synthesis of α-Carboxy Nucleoside Phosphonate Analogues and Evaluation as HIV-1 Reverse Transcriptase-Targeting Agents J. Org. Chem. 2015, 80, 5, 2479–2493.	link	academic
	HIV (cellular assay), low activity (>59 µM)	A. Ford, N.D. Mullins, J. Balzarini, A.R. Maguire Synthesis and Evaluation of Prodrugs of α-Carboxy Nucleoside Phosphonates J. Org. Chem. 2022, 10.1021/acs.joc.2c02135.	link	academic
	HIV (cellular assay) EC50 up to 10.7 µM	H. Li, J.C. Yoo, J.H. Hong Novel Synthesis and Anti-HIV Activity of 4′-Branched Exomethylene Carbocyclic Nucleosides Using a Ring-Closing Metathesis of Triene Nucleosides, Nucleotides and Nucleic Acids 2008, 27 (12), 1238-1249.	link	academic

Structure	Activity	Publications		Stage
	in vitro HSV-1 and HSV-2 assay, MIC₅₀ up to 0.1-0.4 µM	Y.F. Shealy,C.A. O’Dell, W.M. Shannon, G. Arnett Carbocyclic Analogues of 5-Substituted Uracil Nucleosides: Synthesis and Antiviral Activity J. Med. Chem. 1983, 26, 156-161.	link	academic