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47 total results found

Total Syntheses of Natural Products

In this book recently published total synthesis of natural products will be featured. The book is...

Total Synthesis of Thebainone A (P. Metz, 2020)

Total Syntheses of Natural Products Alkaloids

Despite several total syntheses of opiates since the 50s, the construction of these complex alkal...

Total Synthesis of Himalensine A (J. Xu, 2019)

Total Syntheses of Natural Products Alkaloids

Himalensine A (1) is a member of the daphniphyllum alkaloids isolated in 2016 from Daphniphyllum ...

Total Synthesis of Trihydroxytremulenone, Concenolide C and E by Pd-Cyclization (B. Trost, 2020)

Total Syntheses of Natural Products Terpenoids and Terpenes

Complex terpenoids like 10,11,12-trihydroxy tremulenone (1), cocenolide C (2) and E (3, Figure 1)...

Total Synthesis of racemic Phyllantidine by Ring Expansion (J. L. Wood, 2020)

Total Syntheses of Natural Products Alkaloids

Phyllantidine (1) is member of the Securinega alkaloids family named after their first isolation ...

Total Synthesis of Olivil and related Lignans (S. Hanessian, 2020)

Total Syntheses of Natural Products Lignans

Despite reported for the first time over 200 years ago, the lignan olivil (1, see Figure 1) never...

First Total Synthesis of Tuscoron D and E (D. Menche, 2019)

Total Syntheses of Natural Products Polyketides

Almost 20 years ago Prof. G. Höfle and his research group isolated the complex polyketides tuscol...

Total Synthesis of Artemisinin (A. Giannis, 2018)

Total Syntheses of Natural Products Terpenoids and Terpenes

Artemisinin was discovered in the seventies by Tu Youyou (屠呦呦) and the unique structure of this t...

Organic Chemistry

About this page

This page highlights unique research from research groups around the world. It is aimed to prov...

About the Author

About this page

Inspired by natural products, their biosynthesis and impact in medicinal chemistry, I started to ...

First Total Synthesis of Granatumine A (T. R. Newhouse, 2019)

Total Syntheses of Natural Products Alkaloids

In this total synthesis the research group of Timothy Newhouse from Yale University (USA) describ...

First Total Synthesis of Scabrolide A (B. M. Stoltz, 2020)

Total Syntheses of Natural Products Terpenoids and Terpenes

In 2002 Sheu et al. isolated scabrolide A (1) and other natural products from Taiwanese soft cora...

Total Synthesis of Bactobolin A (J. Švenda, 2020)

Total Syntheses of Natural Products Polyketides

Bactobolin A (1) is a complex polyketide firstly isolated in 1979 by S. Kondo et al. from bacteri...

Bioinspired Total Synthesis of Brevianamide (A. Lawrence, 2020)

Total Syntheses of Natural Products Alkaloids

Although already isolated by Birch et al. in 1969, it took 50 years for the first total synthesis...

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First Total Synthesis of Canataxpropellane (T. Gaich, 2020)

Total Syntheses of Natural Products Terpenoids and Terpenes

In their publication in Science (T. Gaich et al. Science, 2020, 367, 676) the research group of T...

First Asymmetric Total Synthesis of Waihoensene (Z. Yang, 2020)

Total Syntheses of Natural Products Terpenoids and Terpenes

Although isolated already in 1997, the complex diterpene waihoensene was firstly synthesized twen...

First Total Synthesis of Darwinolide (M. Christmann, 2018)

Total Syntheses of Natural Products Terpenoids and Terpenes

The diterpenoid darwinolide (1) is a promising candidate for antibiotic research due to his antib...

Total Synthesis of Archazolid F (D. Menche, 2019)

Total Syntheses of Natural Products Polyketides

After the synthesis of archazolid A and B Menche et al. from the University Bonn published the sy...

Total Synthesis of Dysoxylactam A (T. Ye, 2020)

Total Syntheses of Natural Products Polyketides

In this publication from Tao Ye  (叶涛) et al. from Peking University Shenzhen Graduate School (bas...

Total Synthesis of Pimara-15-endiol (T. Magauer, 2020)

Total Syntheses of Natural Products Terpenoids and Terpenes

One of the most interesting biosynthetic transformation is the cyclization of terpenoids to stero...

Polyether

Total Syntheses of Natural Products

Steroids

Total Syntheses of Natural Products

Lignans

Total Syntheses of Natural Products

Alkaloids

Total Syntheses of Natural Products

Polyketides

Total Syntheses of Natural Products

Terpenoids and Terpenes

Total Syntheses of Natural Products

Total Synthesis of Cinnamodial and Dimerization to Capsicodendrin (S. Han, 2020)

Total Syntheses of Natural Products Terpenoids and Terpenes

The terpenoid capsicodendrin (1, Figure 1) is a dimer of cinnamodial (2) which was already isolat...