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35 total results found

Total Synthesis of Pimara-15-endiol (T. Magauer, 2020)

Total Syntheses of Natural Products Terpenoids and Terpenes

One of the most interesting biosynthetic transformation is the cyclization of terpenoids to stero...

Total Synthesis of Olivil and related Lignans (S. Hanessian, 2020)

Total Syntheses of Natural Products Lignans

Despite reported for the first time over 200 years ago, the lignan olivil (1, see Figure 1) never...

Total Synthesis of Cortistatin A (K. C. Nicolaou, 2009)

Total Syntheses of Natural Products Alkaloids

The total synthesis of cortistatin A (1, see Scheme 1) by the K. C. Nicolaou research group publi...

Total Synthesis of Bilobalide (R. Shenvi, 2019)

Total Syntheses of Natural Products Terpenoids and Terpenes

Bilobalide (1, see Figure 1) is a sesquiterpene which can be found in Gingko leaves and is relate...

First Total Synthesis of a Harziane Diterpenoid (E. Carreira, 2019)

Total Syntheses of Natural Products Terpenoids and Terpenes

The E. M. Carreira research group from the ETH Zürich (Swiss) recently published in Angewandte Ch...

Total Synthesis of Cinnamodial and Dimerization to Capsicodendrin (S. Han, 2020)

Total Syntheses of Natural Products Terpenoids and Terpenes

The terpenoid capsicodendrin (1, Figure 1) is a dimer of cinnamodial (2) which was already isolat...

Total Synthesis of Himalensine A (J. Xu, 2019)

Total Syntheses of Natural Products Alkaloids

Himalensine A (1) is a member of the daphniphyllum alkaloids isolated in 2016 from Daphniphyllum ...

Total Synthesis of Trihydroxytremulenone, Concenolide C and E by Pd-Cyclization (B. Trost, 2020)

Total Syntheses of Natural Products Terpenoids and Terpenes

Complex terpenoids like 10,11,12-trihydroxy tremulenone (1), cocenolide C (2) and E (3, Figure 1)...

Total Synthesis of racemic Phyllantidine by Ring Expansion (J. L. Wood, 2020)

Total Syntheses of Natural Products Alkaloids

Phyllantidine (1) is member of the Securinega alkaloids family named after their first isolation ...

First Total Synthesis of Tuscoron D and E (D. Menche, 2019)

Total Syntheses of Natural Products Polyketides

Almost 20 years ago Prof. G. Höfle and his research group isolated the complex polyketides tuscol...

First Total Synthesis of Darwinolide (M. Christmann, 2018)

Total Syntheses of Natural Products Terpenoids and Terpenes

The diterpenoid darwinolide (1) is a promising candidate for antibiotic research due to his antib...

Total Synthesis of Artemisinin (A. Giannis, 2018)

Total Syntheses of Natural Products Terpenoids and Terpenes

Artemisinin was discovered in the seventies by Tu Youyou (屠呦呦) and the unique structure of this t...

First Total Synthesis of Granatumine A (T. R. Newhouse, 2019)

Total Syntheses of Natural Products Alkaloids

In this total synthesis the research group of Timothy Newhouse from Yale University (USA) describ...

First Total Synthesis of Scabrolide A (B. M. Stoltz, 2020)

Total Syntheses of Natural Products Terpenoids and Terpenes

In 2002 Sheu et al. isolated scabrolide A (1) and other natural products from Taiwanese soft cora...

Total Synthesis of Bactobolin A (J. Švenda, 2020)

Total Syntheses of Natural Products Polyketides

Bactobolin A (1) is a complex polyketide firstly isolated in 1979 by S. Kondo et al. from bacteri...

Total Synthesis of Thebainone A (P. Metz, 2020)

Total Syntheses of Natural Products Alkaloids

Despite several total syntheses of opiates since the 50s, the construction of these complex alkal...

Bioinspired Total Synthesis of Brevianamide (A. Lawrence, 2020)

Total Syntheses of Natural Products Alkaloids

Although already isolated by Birch et al. in 1969, it took 50 years for the first total synthesis...

First Total Synthesis of Canataxpropellane (T. Gaich, 2020)

Total Syntheses of Natural Products Terpenoids and Terpenes

In their publication in Science (T. Gaich et al. Science, 2020, 367, 676) the research group of T...

First Asymmetric Total Synthesis of Waihoensene (Z. Yang, 2020)

Total Syntheses of Natural Products Terpenoids and Terpenes

Although isolated already in 1997, the complex diterpene waihoensene was firstly synthesized twen...

Synthesis of Cortistatin A from Prednisone (P. Baran, 2008)

Total Syntheses of Natural Products Alkaloids

For the enantioselective synthesis of complex alkaloid cortistatin A (1), the research group of P...