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29 total results found

First Total Synthesis of Darwinolide (M. Christmann, 2018)

Total Syntheses of Natural Products Terpenoids and Terpenes

The diterpenoid darwinolide (1) is a promising candidate for antibiotic research due to his antib...

First Total Synthesis of a Harziane Diterpenoid (E. Carreira, 2019)

Total Syntheses of Natural Products Terpenoids and Terpenes

The E. M. Carreira research group from the ETH Zürich (Swiss) recently published in Angewandte Ch...

Total Synthesis of Ajudazol A (D. Menche, 2020)

Total Syntheses of Natural Products Polyketides

Ajudazol A (1) is a secondary metabolite of mycxobacterial origin which containing an isochromano...

First Total Synthesis of Glaucocalyxin A (Y. Jia, 2020)

Total Syntheses of Natural Products Terpenoids and Terpenes

Using a radical cyclization strategy at the very beginning of their synthesis, the Yanxing Jia (贾...

First Total Synthesis of Bufospirostenin A (C.-C. Li, 2020)

Total Syntheses of Natural Products Steroids

Bufospirostenin A (1, Figure 1)  is a bioactive steroid from the bile and venom of the toad Bufo ...

Total Synthesis of Cortistatin A (M. Shair, 2008)

Total Syntheses of Natural Products Alkaloids

In one of the early total syntheses of cortistatin A (1, see Figure 1) the research group of Matt...

Synthesis of Cortistatin A from Prednisone (P. Baran, 2008)

Total Syntheses of Natural Products Alkaloids

For the enantioselective synthesis of complex alkaloid cortistatin A (1), the research group of P...

Total Synthesis of Cortistatin A (K. C. Nicolaou, 2009)

Total Syntheses of Natural Products Alkaloids

The total synthesis of cortistatin A (1, see Scheme 1) by the K. C. Nicolaou research group publi...

Total Synthesis of Bilobalide (R. Shenvi, 2019)

Total Syntheses of Natural Products Terpenoids and Terpenes

Bilobalide (1, see Figure 1) is a sesquiterpene which can be found in Gingko leaves and is relate...

Total Synthesis of Himalensine A (J. Xu, 2019)

Total Syntheses of Natural Products Alkaloids

Himalensine A (1) is a member of the daphniphyllum alkaloids isolated in 2016 from Daphniphyllum ...

First Asymmetric Total Synthesis of Waihoensene (Z. Yang, 2020)

Total Syntheses of Natural Products Terpenoids and Terpenes

Although isolated already in 1997, the complex diterpene waihoensene was firstly synthesized twen...

Total Synthesis of Trihydroxytremulenone, Concenolide C and E by Pd-Cyclization (B. Trost, 2020)

Total Syntheses of Natural Products Terpenoids and Terpenes

Complex terpenoids like 10,11,12-trihydroxy tremulenone (1), cocenolide C (2) and E (3, Figure 1)...

Total Synthesis of racemic Phyllantidine by Ring Expansion (J. L. Wood, 2020)

Total Syntheses of Natural Products Alkaloids

Phyllantidine (1) is member of the Securinega alkaloids family named after their first isolation ...

First Total Synthesis of Tuscoron D and E (D. Menche, 2019)

Total Syntheses of Natural Products Polyketides

Almost 20 years ago Prof. G. Höfle and his research group isolated the complex polyketides tuscol...

Total Synthesis of Artemisinin (A. Giannis, 2018)

Total Syntheses of Natural Products Terpenoids and Terpenes

Artemisinin was discovered in the seventies by Tu Youyou (屠呦呦) and the unique structure of this t...

First Total Synthesis of Scabrolide A (B. M. Stoltz, 2020)

Total Syntheses of Natural Products Terpenoids and Terpenes

In 2002 Sheu et al. isolated scabrolide A (1) and other natural products from Taiwanese soft cora...

Total Synthesis of Bactobolin A (J. Švenda, 2020)

Total Syntheses of Natural Products Polyketides

Bactobolin A (1) is a complex polyketide firstly isolated in 1979 by S. Kondo et al. from bacteri...

Total Synthesis of Thebainone A (P. Metz, 2020)

Total Syntheses of Natural Products Alkaloids

Despite several total syntheses of opiates since the 50s, the construction of these complex alkal...

Bioinspired Total Synthesis of Brevianamide (A. Lawrence, 2020)

Total Syntheses of Natural Products Alkaloids

Although already isolated by Birch et al. in 1969, it took 50 years for the first total synthesis...

First Total Synthesis of Cryptotrione (X.S. Peng, 2020)

Total Syntheses of Natural Products Terpenoids and Terpenes

Cryptotrione (1) is a complex terpenoid isolated in 2010. Now Xiao-Shui Peng (彭小水) and coworkers ...