Nucleoside Analogues
Nucleoside analogues (NAs) are a class of compounds known for their antiviral, antibacterial, anticancer, and antifungal properties. They primarily target the replication machinery of pathogens while potentially affecting host cells. NAs have proven effective in treating various viral diseases such as HIV and Hepatitis. In the subsequent chapters synthesis and chemistry of NAs are explored, offering an exhaustive introduction to this fascinating class of compounds.
Adenosine Analogue VV116
The nucleoside analogue VV116 (1, Fig. 1) is a nucleoside analogue derived from remdesivir (2) sh...
Synthesis of Antiviral Nucleoside Analogue Remdesivir
Remdisivir (1) is a nucleoside analogue prodrug of GS-441524 (2, Fig. 1) developed by Gilead Scie...
Synthesis Strategies for Entecavir
Entecavir (1, see Figure 1) is a carbocyclic nucleoside analogue designed to mimic the structural...