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Total Synthesis of Heilonine from the Wieland–Miescher Ketone by Mingji Dai (JACS, 2024)
Heilonine is an alkaloid isolated in 1989 from Fritillaria ussuriensis and belongs to the structu...
About this Site
This website aims to provide an insight into research in organic and medicinal chemistry from int...
Total Synthesis of Pleurotin (Y. Q. Long 2024)
Pleurotin (1, see Fig. 1) is a benzoquinone meroterpenoid that was first isolated in the late 194...
About the Author
Stephan Scheeff Inspired by the fascinating world of natural products, their biosynthesis, and t...
Synthesis Strategies for Entecavir
Entecavir (1, see Figure 1) is a carbocyclic nucleoside analogue designed to mimic the structural...
First Total Synthesis and Structural Revision of Prorocentin (A. Fürstner, 2023)
Prorocentin (1, as shown in Figure 1) is a complex C-35 strain polyketide that was initially repo...
Total Synthesis of Mycinolide IV and Aldgamycin N (A. Fürstner, 2021)
Mycinolide IV (1, Figure 1) and aldgamycin N (2) are complex, bioactive polyketides. The macrolid...
Total Synthesis of Salimabromide (Hai-Hua Lu, 2022)
Salimabromide (1, Figure 1) is a natural product of marine source with an unique structure. Since...
Enantioselective Total Synthesis of Rubellin C (U. Tambar, 2020)
Rubellin C (1, see Figure 1) is a polyketide featuring an anthraquinone skeletal structure. The r...
First Total Synthesis of Tuscoron D and E (D. Menche, 2019)
Almost 20 years ago Prof. G. Höfle and his research group isolated the complex polyketides tuscol...
Total Synthesis and Structural Revision of Amphirionin-2 (H. Fuwa, 2021)
Amphirionin-2 (1, Figure 1) is a linear polyketide isolated in 2015 by Masashi Tsuda and co-worke...
Adenosine Analogue VV116
The nucleoside analogue VV116 (1, Fig. 1) is a nucleoside analogue derived from remdesivir (2) sh...
Synthesis of Antiviral Nucleoside Analogue Remdesivir
Remdisivir (1) is a nucleoside analogue prodrug of GS-441524 (2, Fig. 1) developed by Gilead Scie...
Total Synthesis of Tronocarpine (K. Namba, 2021)
Tronocarpine (1, see Figure 1) is a pentacyclic alkaloid isolated from the plant species Tabernae...
Total Synthesis of Talatisamine (M. Inoue, 2020)
Talatisamine (1, see Figure 1) is a highly oxidized hexacyclic alkaloid. Isolated already almost ...
Total Synthesis of Stephadiamine and Metaphanine (K. Nagasawa, 2021)
Stephadiamine (1, see Figure 1) and metaphanine (2) are two alkaloids with a hasubanan core struc...
Total Synthesis of Ritterazine B (S. Reisman, 2021)
Ritterazine B (1, Figure 1) is an alkaloid bearing a pyrazine core with two pseudodimeric sites. ...
Total Synthesis of Alterbrassicicene C (J. L. Wood, 2022)
Alterbrassicicene C (1) is a diterpenoid with an unusual tetracyclic core structure. John L. Wood...
Total Synthesis of racemic Phyllantidine by Ring Expansion (J. L. Wood, 2020)
Phyllantidine (1) is member of the Securinega alkaloids family named after their first isolation ...
First Total Synthesis of Kopsinitarine E (D. Ma, 2020)
Kopsinitarine E (1) is a polycyclic alkaloid isolated from Kopsia species. In the journal Angewan...