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Total Synthesis of Pladienolide B (M. J. Krische, 2021)

Pladienolide B (1, see Figure 1) is a polyketide bearing multiple stereogenic center. In a publis...

First Total Synthesis of Tuscoron D and E (D. Menche, 2019)

Almost 20 years ago Prof. G. Höfle and his research group isolated the complex polyketides tuscol...

Enantioselective Total Synthesis of Rubellin C (U. Tambar, 2020)

Rubellin C (1, see Figure 1) is a polyketide featuring an anthraquinone skeletal structure. The r...

Formal Total Synthesis of Atropurpuran (K. Tanino, 2020)

Atropurpuran (1) represents a complex diterpenoid featuring a pentacyclic skeleton. The research ...

Total Synthesis of Thebainone A (P. Metz, 2020)

Despite several total syntheses of opiates since the 50s, the construction of these complex alkal...

Total Synthesis of Talatisamine (M. Inoue, 2020)

Talatisamine (1, see Figure 1) is a highly oxidized hexacyclic alkaloid. Isolated already almost ...

Total Synthesis of Tronocarpine (K. Namba, 2021)

Tronocarpine (1, see Figure 1) is a pentacyclic alkaloid isolated from the plant species Tabernae...

Total Synthesis of Stephadiamine and Metaphanine (K. Nagasawa, 2021)

Stephadiamine (1, see Figure 1) and metaphanine (2) are two alkaloids with a hasubanan core struc...

Total Synthesis of Ritterazine B (S. Reisman, 2021)

Ritterazine B (1, Figure 1) is an alkaloid bearing a pyrazine core with two pseudodimeric sites. ...

Total Synthesis of Manginoid A (S. A. Snyder, 2021)

The terpenoid manginoid A (1, see Figure 1) is a polycyclic terpenoid bearing a spirocyclohexaned...

Total Synthesis of Pimara-15-endiol (T. Magauer, 2020)

One of the most interesting biosynthetic transformation is the cyclization of terpenoids to stero...

First Asymmetric Total Synthesis of Waihoensene (Z. Yang, 2020)

Although isolated already in 1997, the complex diterpene waihoensene was firstly synthesized twen...

First Total Synthesis of Scabrolide A (B. M. Stoltz, 2020)

In 2002 Sheu et al. isolated scabrolide A (1) and other natural products from Taiwanese soft cora...

Total Synthesis of Trihydroxytremulenone, Concenolide C and E by Pd-Cyclization (B. Trost, 2020)

Complex terpenoids like 10,11,12-trihydroxy tremulenone (1), cocenolide C (2) and E (3, Figure 1)...

Total Synthesis of Mycinolide IV and Aldgamycin N (A. Fürstner, 2021)

Mycinolide IV (1, Figure 1) and aldgamycin N (2) are complex, bioactive polyketides. They macroli...

Total Synthesis of Dysoxylactam A (T. Ye, 2020)

In this publication from Tao Ye  (叶涛) et al. from Peking University Shenzhen Graduate School (bas...

Total Synthesis of Archazolid F (D. Menche, 2019)

After the synthesis of archazolid A and B Menche et al. from the University Bonn published the sy...

Total Synthesis of Bactobolin A (J. Švenda, 2020)

Bactobolin A (1) is a complex polyketide firstly isolated in 1979 by S. Kondo et al. from bacteri...

Total Synthesis and Structural Revision of Amphirionin-2 (H. Fuwa, 2021)

Amphirionin-2 (1, Figure 1) is a linear polyketide isolated in 2015 by Masashi Tsuda and co-worke...

First Total Synthesis of a Harziane Diterpenoid (E. Carreira, 2019)

The E. M. Carreira research group from the ETH Zürich (Swiss) recently published in Angewandte Ch...