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Inspired by natural products, their biosynthesis and their importance in medicinal chemistry, I s...

Updated 1 week ago by Stephan Scheeff

Total Synthesis of Pladienolide B (M. J. Krische, 2021)

Total Syntheses of Natural Products Polyketides

Pladienolide B (1, see Figure 1) is a polyketide bearing multiple stereogenic center. In a publis...

Updated 1 year ago by Stephan Scheeff

First Total Synthesis of Tuscoron D and E (D. Menche, 2019)

Total Syntheses of Natural Products Polyketides

Almost 20 years ago Prof. G. Höfle and his research group isolated the complex polyketides tuscol...

Updated 1 year ago by Stephan Scheeff

Enantioselective Total Synthesis of Rubellin C (U. Tambar, 2020)

Total Syntheses of Natural Products Polyketides

Rubellin C (1, see Figure 1) is a polyketide featuring an anthraquinone skeletal structure. The r...

Updated 1 year ago by Stephan Scheeff

Formal Total Synthesis of Atropurpuran (K. Tanino, 2020)

Total Syntheses of Natural Products Terpenoids and Terpenes

Atropurpuran (1) represents a complex diterpenoid featuring a pentacyclic skeleton. The research ...

Updated 1 year ago by Stephan Scheeff

Total Synthesis of Thebainone A (P. Metz, 2020)

Total Syntheses of Natural Products Alkaloids

Despite several total syntheses of opiates since the 50s, the construction of these complex alkal...

Updated 1 year ago by Stephan Scheeff

Total Synthesis of Talatisamine (M. Inoue, 2020)

Total Syntheses of Natural Products Alkaloids

Talatisamine (1, see Figure 1) is a highly oxidized hexacyclic alkaloid. Isolated already almost ...

Updated 1 year ago by Stephan Scheeff

Total Synthesis of Tronocarpine (K. Namba, 2021)

Total Syntheses of Natural Products Alkaloids

Tronocarpine (1, see Figure 1) is a pentacyclic alkaloid isolated from the plant species Tabernae...

Updated 1 year ago by Stephan Scheeff

Total Synthesis of Stephadiamine and Metaphanine (K. Nagasawa, 2021)

Total Syntheses of Natural Products Alkaloids

Stephadiamine (1, see Figure 1) and metaphanine (2) are two alkaloids with a hasubanan core struc...

Updated 1 year ago by Stephan Scheeff

Total Synthesis of Ritterazine B (S. Reisman, 2021)

Total Syntheses of Natural Products Alkaloids

Ritterazine B (1, Figure 1) is an alkaloid bearing a pyrazine core with two pseudodimeric sites. ...

Updated 1 year ago by Stephan Scheeff

Total Synthesis of Manginoid A (S. A. Snyder, 2021)

Total Syntheses of Natural Products Terpenoids and Terpenes

The terpenoid manginoid A (1, see Figure 1) is a polycyclic terpenoid bearing a spirocyclohexaned...

Updated 1 year ago by Stephan Scheeff

Total Synthesis of Pimara-15-endiol (T. Magauer, 2020)

Total Syntheses of Natural Products Terpenoids and Terpenes

One of the most interesting biosynthetic transformation is the cyclization of terpenoids to stero...

Updated 1 year ago by Stephan Scheeff

First Asymmetric Total Synthesis of Waihoensene (Z. Yang, 2020)

Total Syntheses of Natural Products Terpenoids and Terpenes

Although isolated already in 1997, the complex diterpene waihoensene was firstly synthesized twen...

Updated 1 year ago by Stephan Scheeff

First Total Synthesis of Scabrolide A (B. M. Stoltz, 2020)

Total Syntheses of Natural Products Terpenoids and Terpenes

In 2002 Sheu et al. isolated scabrolide A (1) and other natural products from Taiwanese soft cora...

Updated 1 year ago by Stephan Scheeff

Total Synthesis of Trihydroxytremulenone, Concenolide C and E by Pd-Cyclization (B. Trost, 2020)

Total Syntheses of Natural Products Terpenoids and Terpenes

Complex terpenoids like 10,11,12-trihydroxy tremulenone (1), cocenolide C (2) and E (3, Figure 1)...

Updated 1 year ago by Stephan Scheeff

Total Synthesis of Mycinolide IV and Aldgamycin N (A. Fürstner, 2021)

Total Syntheses of Natural Products Polyketides

Mycinolide IV (1, Figure 1) and aldgamycin N (2) are complex, bioactive polyketides. They macroli...

Updated 1 year ago by Stephan Scheeff

Total Synthesis of Dysoxylactam A (T. Ye, 2020)

Total Syntheses of Natural Products Polyketides

In this publication from Tao Ye  (叶涛) et al. from Peking University Shenzhen Graduate School (bas...

Updated 1 year ago by Stephan Scheeff

Total Synthesis of Archazolid F (D. Menche, 2019)

Total Syntheses of Natural Products Polyketides

After the synthesis of archazolid A and B Menche et al. from the University Bonn published the sy...

Updated 1 year ago by Stephan Scheeff

Total Synthesis of Bactobolin A (J. Švenda, 2020)

Total Syntheses of Natural Products Polyketides

Bactobolin A (1) is a complex polyketide firstly isolated in 1979 by S. Kondo et al. from bacteri...

Updated 1 year ago by Stephan Scheeff

Total Synthesis and Structural Revision of Amphirionin-2 (H. Fuwa, 2021)

Total Syntheses of Natural Products Polyketides

Amphirionin-2 (1, Figure 1) is a linear polyketide isolated in 2015 by Masashi Tsuda and co-worke...

Updated 1 year ago by Stephan Scheeff