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First Total Synthesis and Structural Revision of Prorocentin (A. Fürstner, 2023)
Prorocentin (1, see Figure 1) is a complex C-35 strain polyketide first reported in 2005 by Tzong...
Total Synthesis of Mycinolide IV and Aldgamycin N (A. Fürstner, 2021)
Mycinolide IV (1, Figure 1) and aldgamycin N (2) are complex, bioactive polyketides. The macrolid...
First Total Synthesis of Tuscoron D and E (D. Menche, 2019)
Almost 20 years ago Prof. G. Höfle and his research group isolated the complex polyketides tuscol...
Enantioselective Total Synthesis of Rubellin C (U. Tambar, 2020)
Rubellin C (1, see Figure 1) is a polyketide featuring an anthraquinone skeletal structure. The r...
Total Synthesis of Salimabromide (Hai-Hua Lu, 2022)
Salimabromide (1, Figure 1) is a natural product of marine source with an unique structure. Since...
Total Synthesis and Structural Revision of Amphirionin-2 (H. Fuwa, 2021)
Amphirionin-2 (1, Figure 1) is a linear polyketide isolated in 2015 by Masashi Tsuda and co-worke...
Adenosine Analogue VV116
The nucleoside analogue VV116 (1, Fig. 1) is a nucleoside analogue derived from remdesivir (2) sh...
Synthesis of Antiviral Nucleoside Analogue Remdesivir
Remdisivir (1) is a nucleoside analogue prodrug of GS-441524 (2, Fig. 1) developed by Gilead Scie...
Total Synthesis of Tronocarpine (K. Namba, 2021)
Tronocarpine (1, see Figure 1) is a pentacyclic alkaloid isolated from the plant species Tabernae...
Total Synthesis of Talatisamine (M. Inoue, 2020)
Talatisamine (1, see Figure 1) is a highly oxidized hexacyclic alkaloid. Isolated already almost ...
Total Synthesis of Stephadiamine and Metaphanine (K. Nagasawa, 2021)
Stephadiamine (1, see Figure 1) and metaphanine (2) are two alkaloids with a hasubanan core struc...
Total Synthesis of Ritterazine B (S. Reisman, 2021)
Ritterazine B (1, Figure 1) is an alkaloid bearing a pyrazine core with two pseudodimeric sites. ...
Total Synthesis of Alterbrassicicene C (J. L. Wood, 2022)
Alterbrassicicene C (1) is a diterpenoid with an unusual tetracyclic core structure. John L. Wood...
Total Synthesis of racemic Phyllantidine by Ring Expansion (J. L. Wood, 2020)
Phyllantidine (1) is member of the Securinega alkaloids family named after their first isolation ...
First Total Synthesis of Kopsinitarine E (D. Ma, 2020)
Kopsinitarine E (1) is a polycyclic alkaloid isolated from Kopsia species. In the journal Angewan...
Total Synthesis of Himalensine A (J. Xu, 2019)
Himalensine A (1) is a member of the daphniphyllum alkaloids isolated in 2016 from Daphniphyllum ...
Total Synthesis of Cortistatin A (K. C. Nicolaou, 2009)
The total synthesis of cortistatin A (1, see Scheme 1) by the K. C. Nicolaou research group publi...
Total Synthesis of Cortistatin A (M. Shair, 2008)
In one of the early total syntheses of cortistatin A (1, see Figure 1) the research group of Matt...
Synthesis of Cortistatin A from Prednisone (P. Baran, 2008)
For the enantioselective synthesis of complex alkaloid cortistatin A (1), the research group of P...
First Total Synthesis of Daphnezomines A and B (C. Li, 2020)
Alkaloids from the plant genus Daphniphyllum are known for their complex structure and attracted ...