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Principles and Concept of the Aldol Reaction
The aldol reaction is a classical C-C bond formation reaction. As exemplified in Scheme 1, the fi...
Cyclisation Reactions in Total Synthesis
Diels-Alder Reaction
Introduction
Total Synthesis of Garryine (Y. Qin, 2023)
Garryine (1, Figure 1) is a hexacyclic diterpenoid isolated from plants of the species of Garrya....
First Total Synthesis of Stemocurtisine (M. Dai, 2026)
Stemocurtisine (1, Fig 1) is an alkaloid isolated from the roots of Stemona curtisii. It was firs...
Enantioselective Total Synthesis of Batrachotoxinin A (T. Luo, 2020)
Batrachotoxinin A (1, see Figure 1) is an alkaloid with a steroidal skeleton. The batrachtoxinins...
About this Site
This website aims to provide highlights of international research in organic and medicinal chemis...
Total Synthesis of Heilonine from the Wieland–Miescher Ketone by Mingji Dai (JACS, 2024)
Heilonine is an alkaloid isolated in 1989 from Fritillaria ussuriensis and belongs to the structu...
Total Synthesis of Pleurotin (Y. Q. Long 2024)
Pleurotin (1, see Fig. 1) is a benzoquinone meroterpenoid that was first isolated in the late 194...
Synthesis Strategies for Entecavir
Entecavir (1, see Figure 1) is a carbocyclic nucleoside analogue designed to mimic the structural...
First Total Synthesis and Structural Revision of Prorocentin (A. Fürstner, 2023)
Prorocentin (1, as shown in Figure 1) is a complex C-35 strain polyketide that was initially repo...
Total Synthesis of Mycinolide IV and Aldgamycin N (A. Fürstner, 2021)
Mycinolide IV (1, Figure 1) and aldgamycin N (2) are complex, bioactive polyketides. The macrolid...
First Total Synthesis of Tuscoron D and E (D. Menche, 2019)
Almost 20 years ago Prof. G. Höfle and his research group isolated the complex polyketides tuscol...
Enantioselective Total Synthesis of Rubellin C (U. Tambar, 2020)
Rubellin C (1, see Figure 1) is a polyketide featuring an anthraquinone skeletal structure. The r...
Total Synthesis of Salimabromide (Hai-Hua Lu, 2022)
Salimabromide (1, Figure 1) is a natural product of marine source with an unique structure. Since...
Total Synthesis and Structural Revision of Amphirionin-2 (H. Fuwa, 2021)
Amphirionin-2 (1, Figure 1) is a linear polyketide isolated in 2015 by Masashi Tsuda and co-worke...
Adenosine Analogue VV116
The nucleoside analogue VV116 (1, Fig. 1) is a nucleoside analogue derived from remdesivir (2) sh...
Synthesis of Antiviral Nucleoside Analogue Remdesivir
Remdisivir (1) is a nucleoside analogue prodrug of GS-441524 (2, Fig. 1) developed by Gilead Scie...
Total Synthesis of Tronocarpine (K. Namba, 2021)
Tronocarpine (1, see Figure 1) is a pentacyclic alkaloid isolated from the plant species Tabernae...