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First Total Synthesis of Tuscoron D and E (D. Menche, 2019)

Almost 20 years ago Prof. G. Höfle and his research group isolated the complex polyketides tuscol...

Enantioselective Total Synthesis of Rubellin C (U. Tambar, 2020)

Rubellin C (1, see Figure 1) is a polyketide featuring an anthraquinone skeletal structure. The r...

Total Synthesis of Mycinolide IV and Aldgamycin N (A. Fürstner, 2021)

Mycinolide IV (1, Figure 1) and aldgamycin N (2) are complex, bioactive polyketides. They macroli...

Total Synthesis of Dysoxylactam A (T. Ye, 2020)

In this publication from Tao Ye  (叶涛) et al. from Peking University Shenzhen Graduate School (bas...

Total Synthesis of Archazolid F (D. Menche, 2019)

After the synthesis of archazolid A and B Menche et al. from the University Bonn published the sy...

Total Synthesis of Bactobolin A (J. Švenda, 2020)

Bactobolin A (1) is a complex polyketide firstly isolated in 1979 by S. Kondo et al. from bacteri...

Total Synthesis and Structural Revision of Amphirionin-2 (H. Fuwa, 2021)

Amphirionin-2 (1, Figure 1) is a linear polyketide isolated in 2015 by Masashi Tsuda and co-worke...

Total Synthesis of Pimara-15-endiol (T. Magauer, 2020)

One of the most interesting biosynthetic transformation is the cyclization of terpenoids to stero...

First Asymmetric Total Synthesis of Waihoensene (Z. Yang, 2020)

Although isolated already in 1997, the complex diterpene waihoensene was firstly synthesized twen...

First Total Synthesis of Scabrolide A (B. M. Stoltz, 2020)

In 2002 Sheu et al. isolated scabrolide A (1) and other natural products from Taiwanese soft cora...

Total Synthesis of Trihydroxytremulenone, Concenolide C and E by Pd-Cyclization (B. Trost, 2020)

Complex terpenoids like 10,11,12-trihydroxy tremulenone (1), cocenolide C (2) and E (3, Figure 1)...

First Total Synthesis of a Harziane Diterpenoid (E. Carreira, 2019)

The E. M. Carreira research group from the ETH Zürich (Swiss) recently published in Angewandte Ch...

Structural Revision and Total Synthesis of ent-Halioxepine (M. Kalesse, 2021)

Halioxepine (1, see Figure 1) is a meroterpene isolated in 2011 by Junichi Tanaka and co-workers ...

Total Synthesis of Tronocarpine (K. Namba, 2021)

Tronocarpine (1, see Figure 1) is a pentacyclic alkaloid isolated from the plant species Tabernae...

Total Synthesis of Talatisamine (M. Inoue, 2020)

Talatisamine (1, see Figure 1) is a highly oxidized hexacyclic alkaloid. Isolated already almost ...

Total Synthesis of Thebainone A (P. Metz, 2020)

Despite several total syntheses of opiates since the 50s, the construction of these complex alkal...

Bioinspired Total Synthesis of Brevianamide (A. Lawrence, 2020)

Although already isolated by Birch et al. in 1969, it took 50 years for the first total synthesis...

First Total Synthesis of Granatumine A (T. R. Newhouse, 2019)

In this total synthesis the research group of Timothy Newhouse from Yale University (USA) describ...

Total Synthesis of racemic Phyllantidine by Ring Expansion (J. L. Wood, 2020)

Phyllantidine (1) is member of the Securinega alkaloids family named after their first isolation ...

Total Synthesis of Himalensine A (J. Xu, 2019)

Himalensine A (1) is a member of the daphniphyllum alkaloids isolated in 2016 from Daphniphyllum ...