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First Total Synthesis and Structural Revision of Prorocentin (A. Fürstner, 2023)

Total Syntheses of Natural Products Polyketides

Prorocentin (1, see Figure 1) is a complex C-35 strain polyketide first reported in 2005 by Tzong...

Updated 1 month ago by Stephan Scheeff

Total Synthesis of Mycinolide IV and Aldgamycin N (A. Fürstner, 2021)

Total Syntheses of Natural Products Polyketides

Mycinolide IV (1, Figure 1) and aldgamycin N (2) are complex, bioactive polyketides. The macrolid...

Updated 1 month ago by Stephan Scheeff

First Total Synthesis of Tuscoron D and E (D. Menche, 2019)

Total Syntheses of Natural Products Polyketides

Almost 20 years ago Prof. G. Höfle and his research group isolated the complex polyketides tuscol...

Updated 1 month ago by Stephan Scheeff

Enantioselective Total Synthesis of Rubellin C (U. Tambar, 2020)

Total Syntheses of Natural Products Polyketides

Rubellin C (1, see Figure 1) is a polyketide featuring an anthraquinone skeletal structure. The r...

Updated 1 month ago by Stephan Scheeff

Total Synthesis of Salimabromide (Hai-Hua Lu, 2022)

Total Syntheses of Natural Products Polyketides

Salimabromide (1, Figure 1) is a natural product of marine source with an unique structure. Since...

Updated 1 month ago by Stephan Scheeff

Total Synthesis and Structural Revision of Amphirionin-2 (H. Fuwa, 2021)

Total Syntheses of Natural Products Polyketides

Amphirionin-2 (1, Figure 1) is a linear polyketide isolated in 2015 by Masashi Tsuda and co-worke...

Updated 1 month ago by Stephan Scheeff

Adenosine Analogue VV116

Nucleoside Analogues

The nucleoside analogue VV116 (1, Fig. 1) is a nucleoside analogue derived from remdesivir (2) sh...

Updated 2 months ago by Stephan Scheeff

Synthesis of Antiviral Nucleoside Analogue Remdesivir

Nucleoside Analogues

Remdisivir (1) is a nucleoside analogue prodrug of GS-441524 (2, Fig. 1) developed by Gilead Scie...

Updated 2 months ago by Stephan Scheeff

Total Synthesis of Tronocarpine (K. Namba, 2021)

Total Syntheses of Natural Products Alkaloids

Tronocarpine (1, see Figure 1) is a pentacyclic alkaloid isolated from the plant species Tabernae...

Updated 2 months ago by Stephan Scheeff

Total Synthesis of Talatisamine (M. Inoue, 2020)

Total Syntheses of Natural Products Alkaloids

Talatisamine (1, see Figure 1) is a highly oxidized hexacyclic alkaloid. Isolated already almost ...

Updated 2 months ago by Stephan Scheeff

Total Synthesis of Stephadiamine and Metaphanine (K. Nagasawa, 2021)

Total Syntheses of Natural Products Alkaloids

Stephadiamine (1, see Figure 1) and metaphanine (2) are two alkaloids with a hasubanan core struc...

Updated 2 months ago by Stephan Scheeff

Total Synthesis of Ritterazine B (S. Reisman, 2021)

Total Syntheses of Natural Products Alkaloids

Ritterazine B (1, Figure 1) is an alkaloid bearing a pyrazine core with two pseudodimeric sites. ...

Updated 2 months ago by Stephan Scheeff

Total Synthesis of Alterbrassicicene C (J. L. Wood, 2022)

Total Syntheses of Natural Products Terpenoids and Terpenes

Alterbrassicicene C (1) is a diterpenoid with an unusual tetracyclic core structure. John L. Wood...

Updated 2 months ago by Stephan Scheeff

Total Synthesis of racemic Phyllantidine by Ring Expansion (J. L. Wood, 2020)

Total Syntheses of Natural Products Alkaloids

Phyllantidine (1) is member of the Securinega alkaloids family named after their first isolation ...

Updated 2 months ago by Stephan Scheeff

First Total Synthesis of Kopsinitarine E (D. Ma, 2020)

Total Syntheses of Natural Products Alkaloids

Kopsinitarine E (1) is a polycyclic alkaloid isolated from Kopsia species. In the journal Angewan...

Updated 2 months ago by Stephan Scheeff

Total Synthesis of Himalensine A (J. Xu, 2019)

Total Syntheses of Natural Products Alkaloids

Himalensine A (1) is a member of the daphniphyllum alkaloids isolated in 2016 from Daphniphyllum ...

Updated 2 months ago by Stephan Scheeff

Total Synthesis of Cortistatin A (K. C. Nicolaou, 2009)

Total Syntheses of Natural Products Alkaloids

The total synthesis of cortistatin A (1, see Scheme 1) by the K. C. Nicolaou research group publi...

Updated 2 months ago by Stephan Scheeff

Total Synthesis of Cortistatin A (M. Shair, 2008)

Total Syntheses of Natural Products Alkaloids

In one of the early total syntheses of cortistatin A (1, see Figure 1) the research group of Matt...

Updated 2 months ago by Stephan Scheeff

Synthesis of Cortistatin A from Prednisone (P. Baran, 2008)

Total Syntheses of Natural Products Alkaloids

For the enantioselective synthesis of complex alkaloid cortistatin A (1), the research group of P...

Updated 2 months ago by Stephan Scheeff

First Total Synthesis of Daphnezomines A and B (C. Li, 2020)

Total Syntheses of Natural Products Alkaloids

Alkaloids from the plant genus Daphniphyllum are known for their complex structure and attracted ...

Updated 2 months ago by Stephan Scheeff