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About the Author

About

Stephan Scheeff Inspired by the fascinating world of natural products, their biosynthesis, and t...

Updated 6 months ago by Stephan Scheeff

About this Site

About

This website is intended to provide a unique insight into research in organic and medicinal che...

Updated 6 months ago by Stephan Scheeff

Synthesis Strategies for Entecavir

Nucleoside Analogues

Entecavir (1, see Figure 1) is a carbocyclic nucleoside analogue designed to mimic the structural...

Updated 6 months ago by Stephan Scheeff

First Total Synthesis and Structural Revision of Prorocentin (A. Fürstner, 2023)

Total Syntheses of Natural Products Polyketides

Prorocentin (1, as shown in Figure 1) is a complex C-35 strain polyketide that was initially repo...

Updated 6 months ago by Stephan Scheeff

Total Synthesis of Mycinolide IV and Aldgamycin N (A. Fürstner, 2021)

Total Syntheses of Natural Products Polyketides

Mycinolide IV (1, Figure 1) and aldgamycin N (2) are complex, bioactive polyketides. The macrolid...

Updated 1 year ago by Stephan Scheeff

Total Synthesis of Salimabromide (Hai-Hua Lu, 2022)

Total Syntheses of Natural Products Polyketides

Salimabromide (1, Figure 1) is a natural product of marine source with an unique structure. Since...

Updated 1 year ago by Stephan Scheeff

Enantioselective Total Synthesis of Rubellin C (U. Tambar, 2020)

Total Syntheses of Natural Products Polyketides

Rubellin C (1, see Figure 1) is a polyketide featuring an anthraquinone skeletal structure. The r...

Updated 1 year ago by Stephan Scheeff

First Total Synthesis of Tuscoron D and E (D. Menche, 2019)

Total Syntheses of Natural Products Polyketides

Almost 20 years ago Prof. G. Höfle and his research group isolated the complex polyketides tuscol...

Updated 1 year ago by Stephan Scheeff

Total Synthesis and Structural Revision of Amphirionin-2 (H. Fuwa, 2021)

Total Syntheses of Natural Products Polyketides

Amphirionin-2 (1, Figure 1) is a linear polyketide isolated in 2015 by Masashi Tsuda and co-worke...

Updated 1 year ago by Stephan Scheeff

Adenosine Analogue VV116

Nucleoside Analogues

The nucleoside analogue VV116 (1, Fig. 1) is a nucleoside analogue derived from remdesivir (2) sh...

Updated 1 year ago by Stephan Scheeff

Synthesis of Antiviral Nucleoside Analogue Remdesivir

Nucleoside Analogues

Remdisivir (1) is a nucleoside analogue prodrug of GS-441524 (2, Fig. 1) developed by Gilead Scie...

Updated 1 year ago by Stephan Scheeff

Total Synthesis of Tronocarpine (K. Namba, 2021)

Total Syntheses of Natural Products Alkaloids

Tronocarpine (1, see Figure 1) is a pentacyclic alkaloid isolated from the plant species Tabernae...

Updated 1 year ago by Stephan Scheeff

Total Synthesis of Talatisamine (M. Inoue, 2020)

Total Syntheses of Natural Products Alkaloids

Talatisamine (1, see Figure 1) is a highly oxidized hexacyclic alkaloid. Isolated already almost ...

Updated 1 year ago by Stephan Scheeff

Total Synthesis of Stephadiamine and Metaphanine (K. Nagasawa, 2021)

Total Syntheses of Natural Products Alkaloids

Stephadiamine (1, see Figure 1) and metaphanine (2) are two alkaloids with a hasubanan core struc...

Updated 1 year ago by Stephan Scheeff

Total Synthesis of Ritterazine B (S. Reisman, 2021)

Total Syntheses of Natural Products Alkaloids

Ritterazine B (1, Figure 1) is an alkaloid bearing a pyrazine core with two pseudodimeric sites. ...

Updated 1 year ago by Stephan Scheeff

Total Synthesis of Alterbrassicicene C (J. L. Wood, 2022)

Total Syntheses of Natural Products Terpenoids and Terpenes

Alterbrassicicene C (1) is a diterpenoid with an unusual tetracyclic core structure. John L. Wood...

Updated 1 year ago by Stephan Scheeff

Total Synthesis of racemic Phyllantidine by Ring Expansion (J. L. Wood, 2020)

Total Syntheses of Natural Products Alkaloids

Phyllantidine (1) is member of the Securinega alkaloids family named after their first isolation ...

Updated 1 year ago by Stephan Scheeff

First Total Synthesis of Kopsinitarine E (D. Ma, 2020)

Total Syntheses of Natural Products Alkaloids

Kopsinitarine E (1) is a polycyclic alkaloid isolated from Kopsia species. In the journal Angewan...

Updated 1 year ago by Stephan Scheeff

Total Synthesis of Himalensine A (J. Xu, 2019)

Total Syntheses of Natural Products Alkaloids

Himalensine A (1) is a member of the daphniphyllum alkaloids isolated in 2016 from Daphniphyllum ...

Updated 1 year ago by Stephan Scheeff

Total Synthesis of Cortistatin A (K. C. Nicolaou, 2009)

Total Syntheses of Natural Products Alkaloids

The total synthesis of cortistatin A (1, see Scheme 1) by the K. C. Nicolaou research group publi...

Updated 1 year ago by Stephan Scheeff