Polyketides
Total Synthesis of Ajudazol A (D. Menche, 2020)
Ajudazol A (1) is a secondary metabolite of mycxobacterial origin which containing an isochromano...
Total Synthesis and Structural Revision of Amphirionin-2 (H. Fuwa, 2021)
Amphirionin-2 (1, Figure 1) is a linear polyketide isolated in 2015 by Masashi Tsuda and co-worke...
Total Synthesis of Archazolid F (D. Menche, 2019)
After the synthesis of archazolid A and B Menche et al. from the University Bonn published the sy...
Total Synthesis of Bactobolin A (J. Švenda, 2020)
Bactobolin A (1) is a complex polyketide firstly isolated in 1979 by S. Kondo et al. from bacteri...
Total Synthesis of Dysoxylactam A (T. Ye, 2020)
In this publication from Tao Ye (叶涛) et al. from Peking University Shenzhen Graduate School (bas...
Total Synthesis of Mycinolide IV and Aldgamycin N (A. Fürstner, 2021)
Mycinolide IV (1, Figure 1) and aldgamycin N (2) are complex, bioactive polyketides. The macrolid...
Total Synthesis of Pladienolide B (M. J. Krische, 2021)
Pladienolide B (1, see Figure 1) is a polyketide bearing multiple stereogenic center. In a publis...
First Total Synthesis and Structural Revision of Prorocentin (A. Fürstner, 2023)
Prorocentin (1, as shown in Figure 1) is a complex C-35 strain polyketide that was initially repo...
Enantioselective Total Synthesis of Rubellin C (U. Tambar, 2020)
Rubellin C (1, see Figure 1) is a polyketide featuring an anthraquinone skeletal structure. The r...
Total Synthesis of Salimabromide (Hai-Hua Lu, 2022)
Salimabromide (1, Figure 1) is a natural product of marine source with an unique structure. Since...
First Total Synthesis of Tuscoron D and E (D. Menche, 2019)
Almost 20 years ago Prof. G. Höfle and his research group isolated the complex polyketides tuscol...